BioCover: First Allograft Composed of Amnion for Use in Treatment of Gingival Recession
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Human amnion tissue is the inner most lining of the amniotic sac. This unique, collagenous membrane represents the part of the placenta which encloses the unborn baby through term. Each layer of amnion tissue consists of a single layer of epithelium cells, thin reticular fibers (basement membrane), a thick compact layer, and a fibroblast layer. The basement membrane of amnion tissue contains collagen types III, IV and V and cell-adhesion bioactive factors including fibronectin and laminins.
BioCover represents the first allograft composed of amnion tissue for use as a wound covering for the treatment of gingival recession. BioCover is a processed, dehydrated graft containing multiple layers of human amnion tissue. Each BioCover is sealed in a double pouch configuration and terminally sterilized.
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BioCover features an “SM” embossed onto the BioCover surface. This allows clinicians to easily identify the basement membrane side of BioCover and helps ensure proper orientation during placement. |
The light microscope picture, at 100x magnification, details the multiple layers of a hydrated BioCover. Photograph courtesy of Charley Cobb, DDS, PhD |
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BioCover does not require hydration prior to use. It rehydrates upon placement and naturally self-adheres to the exposed root surface and proximal bone. This unique attribute eliminates the need to suture the graft into place. The illustration below highlights graft placement, the graft self-adhering to the defect, and closure of the surgical site.

BioCover is for single use only. The product can be stored at room temperature, has a five year shelf life, and is available in three sizes. Generally, a small can treat one tooth, a medium, up to three teeth, and a large, up to an entire quadrant.





5 Responses to “ BioCover: First Allograft Composed of Amnion for Use in Treatment of Gingival Recession ”
how long will be resorbed?if expose in oral cavity
via secondary healing?thanks.
How much is the resorption time of this membrane? Can it be used in implant surgeries???
Respected sir,
Im dr.sam post graduate doing masters in dept. of periodontology i want to do my dissertation on this product.please inform me about the cost and its availability and studies alredy conducted.
Dear sir,
i would like to understand is this membrane requires bone graft material in vertical bone defects?
is it resorbable or does it require a second surgery for its removal?
and is there any providers for this material in the middle east?
THANK YOU
Dr.Tamer.H Zayed,BDS
A.D.R.C
Dear sir,
my question is how much the price of this membrane,and if need to bone graft or other materials
best regards
Dr.Waleed Alnuaimi
Baghdad-Iraq