OraVerse for Rapid Reversal of Local Anesthesia: Anybody Have Success with This?

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We now have an agent for the rapid reversal of local anesthesia – phentolamine mesylate [OraVerse]. Is anybody using this? One of the most frequent complaints I hear from my patients is that the anesthesia lasts too long – especially inferior alveolar blocks. Some of my patients hate the prolonged numbness so much that they prefer to take the pain of having dental treatment without anesthesia which drives me crazy as the squeak or shudder whenever I do anything that hurts. I would be happy to bear the increased cost of using this reversal agent to get more of my patients to accept profound local anesthesia. But I would like to know that it really works.

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6 Responses to “ OraVerse for Rapid Reversal of Local Anesthesia: Anybody Have Success with This? ”

  • Karen Williamson March 18th, 2009

    I have not used Oraverse yet, but would like to try it. Where can I purchase this?

  • David Chin March 23rd, 2009

    I have just received my order of Oraverse and am excited to begin use of the product. Friends were involved in the clinical studies at UCLA. see JADA August 2008 for published results or Novalar’s website www.novalar.com, a rep would be happy to call on you, especially if you are in California as the company is based in San Diego. My understanding is that best to use/inject after preparing the tooth and ready to fill. Clinical studies show that on the average, can cut postanesthesia time from 2 hours to 1 hour. This is average, so there can be shorter or longer. Comes in cartridges with green id band and can be injected using any syringe. If ordering a box of 50 cartridges, the company will give you an aspirating syringe. This is a pedo practice so we are excited to try this - can you tell - especially, since first patient this morning was upset to have local - not for the injection, but because the fat lip after last visit.

  • David Chin March 25th, 2009

    Have now been using OraVerse since Tuesday. Followed up on one mandibular block patient and anesthesia wore off one hour after reversing. Did maxillary reversal on one of my hygienist this afternoon and it wore off 15 minutes after reversing. Great results?

  • David Chin March 25th, 2009

    Have now been using OraVerse since Tuesday. Followed up on one mandibular block patient and anesthesia wore off one hour after reversing. Did maxillary reversal on one of my hygienist this afternoon and it wore off 15 minutes after reversing. Great results!

  • Greg Cook June 9th, 2009

    Pretty pricey for an hour less of numbness: #13.50 per cartridge if you buy 50 or $17.50 if you buy ten. I suspect that not many patients would opt for paying $20 for the reversal, but I could be wrong. Before I buy it I’m going to survey my patients. Who knows…it may be extremely desireable. I’ve been using Septocaine for lower first molars forward with a buccal infiltration after first numbing with Carbocaine (Articaine is quite irritating upon injection), and because it has epi, I’d prefer to use Oraverse after to avoid or reduce the chance of lip injury. Having the tongue not numb is a nice advantage of Septocaine on the lower arch. Does anyone know why Septocaine isn’t available without epi?

  • dan p July 1st, 2009

    As a busy executive, not allowing me the option to pay for this product is a complete disservice, especially since most dental practices inflate the cost of zoom. In this economy I cant afford to lose work, not giving me the option to purchase this product is just wrong !!

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