Micro-porous Cytoflex® Resorb membranes consist of three integral layers. The embossed gingival interface layer is designed to promote gingival tissue attachment. The middle layer is constructed of long lasting fabric filament to prevent fibroblast down growth. The defect interface layer is made to enhance adherence to the surrounding defect surface and to prevent fibroblasts from reaching the wound. All three micro-porous layers are structurally integrated, resulting in a flexible membrane with superb handling properties and high nutrient permeability.
Made of biocompatible poly (lactide-co-glycolide) copolymers, Cytoflex® Resorb membrane is non-pyrogenic, non-immunogenic and maintains a barrier framework for up to 4 months after implantation. The material is completely dissolved within 6 months. The resorbable membrane does not require a second retrieval procedure.
Cytoflex Resorb Study
The regenerative capacity of Cytoflex® Resorb barriers was evaluated in a beagle dog model. Bilateral infrabony defects were surgically created at the distal aspects of both mandibles in eight beagle dogs. Subsequently, the defects were treated with a GTR procedure using Cytoflex® Resorb barriers. The animals were euthanized at 4, 8, 16 and 24 weeks post-operation. Histotological analysis (below) demonstrates that Cytoflex® Resorb membranes are effective at regenerating new cementum, periodontal ligament and alveolar bone tissue in the protected infrabony defect. Over time, the regenerated tissues remodeled and organized into matured tissue. Post-operation, wound healing was calm and uneventful. The barrier frame remains largely intact up to 16 weeks and is completely resorbed at 24 weeks after implantation.
This case involved a 70-year old male who presented with a failing bridge in the lower right posterior quadrant. GBR was performed using DALI Mineralized Cortical Cancellous Allograft and OsseoSeal.